Guadeloupe was populated from 300 BC by the Arawak Amerindians, who fished and developed agriculture on the island. It was next inhabited by the Caribs, who pushed out most of the Arawak in the 8th century, and who renamed the island "Karukera" or the "Island of beautiful waters".

During his second trip to America Christopher Columbus became the first European to land on Guadeloupe on 14 November 1493. He called it Santa María de Guadalupe de Extremadura, after the image of the Virgin Mary venerated at the Spanish monastery of Villuercas, in Guadalupe, Extremadura.